Sleep
Research Peptides

Sleep research peptides are compounds studied for their effects on sleep architecture, delta wave induction, HPA axis modulation, and circadian rhythm regulation in preclinical models. The most studied is DSIP (Delta Sleep-Inducing Peptide), a nonapeptide that modulates corticotropin release and is associated with delta-wave sleep induction in EEG research. Related compounds with anxiolytic and sleep-adjacent properties include Selank and Epithalon. All are.

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from the venous blood of sleeping rabbits and first described by Monnier et al. (1977). Research has demonstrated its ability to induce delta wave sleep in EEG studies and modulate hypothalamic-pituitary-adrenal (HPA) axis activity, specifically attenuating corticotropin-releasing hormone (CRH) release. Additional research has examined its role in stress response, pain modulation, and rhythmic neuroendocrine regulation. Available from Stackpure in multiple formats..

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a tuftsin analogue that modulates the GABAergic and serotonergic systems, producing anxiolytic activity in preclinical models without the sedation or dependence risks associated with classic benzodiazepines. Its HPA axis modulation (reducing IL-6 and other stress cytokines) makes it relevant for research combining anxiety and sleep-adjacent outcomes. Selank is classically studied as a nasal spray due to direct olfactory bulb delivery and rapid absorption through nasal mucosa.

Epithalon (Ala-Glu-Asp-Gly) was originally developed as a synthetic analogue of the pineal gland extract epithalamin. Research by Khavinson's group at the St. Petersburg Institute has shown that Epithalon normalises pineal function and melatonin secretion patterns in aged subjects, relevant to age-related circadian rhythm disruption and sleep quality deterioration. This pineal-gland connection makes it one of the few peptides with both telomere/longevity research data and circadian/sleep research context..

Yes. Stackpure ships research peptides to the USA, UK, Canada, and Australia with third-party COA on every order. Delivery is 1–3 business days to the USA, UK, Canada, and Australia.