Sexual Health
Research Peptides

Sexual health research peptides are compounds studied for their effects on the melanocortin system, hypothalamic-pituitary-gonadal (HPG) axis, and associated pathways that regulate libido and sexual function in preclinical models. Key compounds include PT-141 (Bremelanotide, MC4R agonist), Kisspeptin-10 (GPR54 agonist, GnRH pulsatility), and Melanotan II (MC1R/MC4R agonist, tanning and libido research). All are.

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist, with primary activity at MC3R and MC4R in the hypothalamus. Unlike PDE5 inhibitors that act peripherally on vasculature, PT-141 acts centrally via the melanocortin system to influence sexual arousal. It is a derivative of Melanotan II with the lactam ring structure that reduces tanning activity while retaining central melanocortin signalling. FDA-approved as Vyleesi for premenopausal hypoactive sexual desire disorder, making it one of the few approved drugs in this class. Available from Stackpure as a research vial, pre-mixed solution, or nasal spray.

Kisspeptin-10 is a 10-amino acid fragment of kisspeptin (KISS1 gene product) that activates the GPR54 (KISS1R) receptor in the hypothalamus. Kisspeptin neurons are the critical upstream regulator of GnRH pulsatility, and by extension, the entire HPG axis. Research has demonstrated that Kisspeptin-10 administration produces pulsatile LH release in both males and females, with potential utility in research of hypogonadism, pubertal timing disorders, and HPG axis modulation. Clinical studies have demonstrated safety in IV and intranasal administration routes..

Melanotan II (MT-II) is a cyclic analogue of alpha-MSH with broad melanocortin receptor activity (MC1R through MC5R), producing both skin tanning effects (via MC1R) and central sexual arousal effects (via MC3R/MC4R). PT-141 (Bremelanotide) was developed from Melanotan II with structural modifications that maintain central MC3R/MC4R agonism for sexual arousal research while substantially reducing skin tanning activity. Melanotan II thus has a dual research application (tanning + sexual health); PT-141 is more selective for central melanocortin research.

Yes. Stackpure ships research peptides to the USA, UK, Canada, and Australia with third-party COA on every order. Delivery is 1–3 business days to the USA, UK, Canada, and Australia..