Cognitive
Research Peptides

Cognitive research peptides are compounds studied for their effects on neuroplasticity, neuroprotection, BDNF upregulation, synaptogenesis, and neurotransmitter regulation in preclinical models. Key compounds include Semax (ACTH analogue, BDNF upregulation), Selank (tuftsin analogue, anxiolytic/nootropic), Dihexa (HGF potentiator, synaptic facilitation), 5-Amino-1MQ (NNMT inhibitor, NAD+ pathway), and NSI-189 (hippocampal neurogenesis). All are.

Semax (ACTH(4-7)PGP) targets the BDNF/VEGF/ACTH axis, its primary research utility is in neuroprotection, acute cognitive enhancement models, and recovery from neurological insult. It has Russian Phase II clinical data in stroke recovery. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a tuftsin analogue with a distinct mechanism: anxiolytic activity via GABAergic and serotonergic modulation, with secondary immunomodulatory effects. Semax excels for neuroprotective and cognitive enhancement protocols; Selank is stronger for anxiety-stress axis modulation models.

Dihexa (N-hexanoic-Tyr-Ile-(6)aminohexanoic amide) potentiates HGF (hepatocyte growth factor) signalling by facilitating its binding to the MET receptor, a pathway involved in synaptogenesis and long-term potentiation. Published research by McCoy et al. (Washington State University) showed Dihexa improved cognitive task performance in rodent models at doses reported to be approximately 7–8 orders of magnitude lower than BDNF. Its lipophilic nature suggests CNS penetrance, making it an active area of nootropic research..

Cognitive research peptides are available from Stackpure in multiple formats. Semax and Selank are classically studied as nasal sprays, the nasal mucosa offers direct access to the olfactory bulb and rapid systemic absorption. Dihexa, 5-Amino-1MQ, and related compounds are available as vials, pre-mixed solutions, and oral capsules. The best format for research depends on the specific route of administration in the protocol.

Yes. Stackpure ships research-grade cognitive peptides to the USA, UK, Canada, and Australia with third-party COA on every order. Delivery is 1–3 business days to the USA, UK, Canada, and Australia.